SAG: a Schwann cell membrane glycoprotein
نویسندگان
چکیده
منابع مشابه
SAG: a Schwann cell membrane glycoprotein.
We report on characterization of a 170,000 Da glycoprotein found exclusively in the PNS. We refer to this protein as the Schwann cell membrane glycoprotein (SAG). SAG contains the HNK-1 carbohydrate, which is considered by some to be a marker of adhesion molecules. Its N-terminal sequence is not similar to previously known polypeptide sequences. SAG is found exclusively in the PNS, is present i...
متن کاملMigration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin
Laminin is a large (greater than 850-kdalton) glycoprotein that is localized within basement membranes. Recent work has indicated that this protein is present within the endoneurium of mouse sciatic nerve. Furthermore, it has been shown that a rat Schwannoma cell line, RN22F, produced laminin and that laminin promoted the attachment of these cells to bacterial plastic. This report presents evid...
متن کاملIntestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis
The cell surface membranes of mitotically active crypt cells from rat intestinal epithelium were found to have glycosyltransferase activities and endogenous acceptors not found on the differentiating villus cells. Rat intestinal epithelial cells were isolated as intact cells from different levels of the villus and crypt areas representing sequential stages of cellular differentiation. Incubatio...
متن کاملSchwann cell expression of a major myelin glycoprotein in the absence of myelin assembly.
Quiescent Schwann cells in the distal segment of the permanently transected nerve produced basal levels of the major myelin glycoprotein, P0, in the absence of myelin assembly. Low levels of P0 could be detected at 35 days after transection by autoradiographic analysis of radioiodinated lectin binding after protein separation by high-resolution sodium dodecyl sulfate pore gradient electrophores...
متن کاملMyelin-associated glycoprotein and myelinating Schwann cell-axon interaction in chronic B,B'-iminodipropionitrile neuropathy
The myelin-associated glycoprotein (MAG) is a heavily glycosylated integral membrane glycoprotein which is a minor component of isolated rat peripheral nervous system (PNS) myelin. Immunocytochemically MAG has been localized in the periaxonal region of PNS myelin sheaths. The periaxonal localization and biochemical features of MAG are consistent with the hypothesis that MAG plays a role in main...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1992
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.12-06-02177.1992